The occasional occurrence of a paretic gold curve in cases that were not paresis, and the occasional diagnosis of paresis without a paretic gold curve suggested that a closer study of this particular colloidal gold reaction should be made. A review of the rather extensive literature that has grown up since Lange1 first introduced this test in 1912 shows that various conclusions have been drawn concerning the value of the paretic curve. These conclusions, however, were based on a more or less limited number of cases.
At this hospital about 8,400 colloidal gold tests have been made on about 7,100 different cerebrospinal fluids. Of this number, 677 fluids gave paretic curves, and these constitute the basis for this study. A large majority of the patients coming to this hospital are in the early stages of their disease, and consequently these findings are those of the early stages, and are,
THOMPSON LJ. INTERPRETATION OF THE "PARETIC CURVE" IN LANGE'S COLLOIDAL GOLD TEST. Arch NeurPsych. 1921;5(2):131–145. doi:10.1001/archneurpsyc.1921.02180260020003
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