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Lange's colloidal gold reaction has been found to be a highly satisfactory aid in the diagnosis of such diseases as paresis, tabes, syphilitic leptomeningitis and the like. At Bellevue Hospital, for some years past, we have been using this test as a routine measure in conjunction with the Wassermann reaction, and the result of a comparative study of the two will be published at another time. Suffice it to say for the present that, in our experience, the colloidal gold reaction is as reliable in the diagnosis of cerebrospinal syphilis as is the Wassermann, if not more so. That the test is not more widely employed is due, we believe, to technical difficulties, since even though great pains are taken, a considerable percentage of all solutions prepared are found to be useless, either because of cloudiness or excessive variations in sensitiveness. After experimenting extensively with various methods, we have found