This article contains a brief review of the histopathologic changes in multiple sclerosis studied on material from thirteen cases. Two cases came from the neurologic service of Cook County Hospital; for two I am indebted to Dr. Peter Bassoe of Chicago; for one to Dr. Theophil Klingman of Ann Arbor, Michigan, and for eight to Dr. Alfons Jacob of Hamburg, Germany.
In addition, four other cases were studied; two apparently normal cords, one cord from a case of capsular hemiplegia and one from a case of Recklinghausen's disease. The findings were contrasted.
The best known and the most notable characteristic features of multiple sclerosis are the so-called patches of sclerosis. Scattered throughout the central nervous system and varying in size and form they preferably affect the white substance, its long or short nerve fibers; they may be symmetrical or asymmetrical and may invade even the peripheral nerves (Strahüber,1 Schob
HASSIN GB. STUDIES IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS. Arch NeurPsych. 1922;7(5):589–607. doi:10.1001/archneurpsyc.1922.02190110040005
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