The spinal cord has been little implicated in epidemic encephalitis and I know of no case except the one I now report in which intense inflammation was found as low as the lumbar region. The case reported in this paper is interesting in its symptoms suggesting brain tumor; in its pathology presenting a myelo-encephalitis; and in the resemblance of its lesions to those of multiple sclerosis, affording support for the theory of the inflammatory origin of the latter disease.
Nuclear stains in this case yielded different findings from those of multiple sclerosis in the intense perivascular infiltration and the presence of many fatty granular or gitter cells in the tissues, and yet it seems reasonable to suppose that had death been delayed a year or more the structure of these sclerotic areas would have resembled that of the areas in multiple sclerosis. The Weigert hematoxylin stain gives findings closely resembling
WILLIAM G. SPILLER. EPIDEMIC ENCEPHALITIS WITH MYELITIS. Arch NeurPsych. 1922;7(6):739–744. doi:10.1001/archneurpsyc.1922.02190120060006