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January 1923

LESIONS IN THE BRAIN OF A PATIENT WITH POSTENCEPHALITIC PARALYSIS AGITANS

Author Affiliations

MINNEAPOLIS

From the Neuropathology Laboratory, University of Minnesota Medical School, Minneapolis.

Arch NeurPsych. 1923;9(1):47-58. doi:10.1001/archneurpsyc.1923.02190190050005
Abstract

The termination of certain cases of epidemic encephalitis in a state similar to paralysis agitans has been the subject of common observation and much comment, but our knowledge of the pathology of this type has been largely deductive. That the acute cases have shown the most marked lesions in the basal ganglions, midbrain, pons and medulla, has been interpreted largely in the light of the work of Hunt1 who described progressive atrophy of the globus pallidus in a case of the juvenile form of paralysis agitans. It has thus been supposed that the symptomatology of postencephalitic parkinsonianism is based on degenerations in the corpus striatum, but observations on the pathologic anatomy have largely been lacking. So far as I have been able to determine, the reports of Foix2 and Goldstein3 are the only ones dealing with this question from the objective point of view. The following case

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