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June 1923

IMPLANTATION OF BACILLUS ACIDOPHILUS IN PERSONS WITH PSYCHOSES

Arch NeurPsych. 1923;9(6):769-777. doi:10.1001/archneurpsyc.1923.02190240082005
Abstract

HISTORICAL  In 1912, Berthelot and Bertrand1 described an organism which they isolated from human stools and called Bacillus aminophilus. Among other characteristics, it showed a marked ability to decarboxylate and deaminize amino-acids. Also, it was capable of producing histamine from histidine. Holmes and Rettinger2 alleged that dementia praecox was caused by the production of histamine by this organism in the intestinal tract.From a study of the frequency of B. aminophilus in the stools of patients with dementia praecox, Jones3 was unable to support the assumption of Holmes and Rettinger. He found: that this organism was present only in the proportion of from 1 to 20,000 to 1 to 100,000 of living bacteria; that it was found with a frequency usual in normal persons; that the histamine present was produced by other intestinal bacteria; that B. aminophilus did not utilize the carboxyl radical (COOH) of histidine if

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