On March 10, 1923, three patients, two brothers and a sister, all alleged to be insane, were brought to the Cook County Psychopathic Hospital. The three had been living in the same apartment with the wife of the elder brother, to whom he had been married about three years. Another brother acted as janitor for the building and lived in the basement. This brother and his wife stated that mental symptoms were noticed first in the elder brother about four months before and that the sister and younger brother first showed evidence of mental disturbance about two months later. All three had been very greatly depressed for one month. At times all of them had been agitated and the household had been sleepless most of the time. The elder brother spoke of suicide and the sister had twice placed a rope around her neck to hang herself. Shortly before admission