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From Lissauer to Kaes there was a tendency to consider general paralysis a system disease involving largely the second and third layer of Meynert. Schaffer accused not so much specific layers but rather the association areas of Flechsig. Nissl and Alzheimer turned their attention more to the histologic process and they and Noguchi brought about the collapse of the notion of toxins and a system disease. Spielmeyer claimed the existence of both factors. Bielschowsky, however, considered the changes of glia and vessels of the degeneration patches as inflammatory and not purely parenchymatous, and Jakob found spirochetes in these foci. All this does not, however, discourage further efforts to correlate the localization and the symptoms, such as were undertaken by Wada for dementia praecox, 1910, (second and third Meynert layer) and since by Josephy (third and fifth layer). Vogt also has furnished a few examples. Saito aims to be more systematic