In the study of the varieties of insanity, it is difficult to see any action on the part of the organism indicative of a mobilization of its physiologic forces tending toward a spontaneous recovery. There is no leukocytosis, no vomiting to evacuate a poison, no rapid pulse to overcome the effects of the inroad of disease. Nor is there seen the compensatory action observable in other forms of disease. There seems to be established a vicious physiologic circle and I shall endeavor to show that there are "physiologic patterns" evidenced by the response of the involuntary nervous system, and that these have correspondence with mental patterns so that there can be differentiated certain nervous mechanisms in the various psychoses which, taken together, form an approach for the application of the principles of general medicine to the psychoses.
Just as the psychoses fall into several groups or patterns, such as depression
SEYMOUR DE WITT LUDLUM. PHYSIOLOGIC CONDITIONS UNDER WHICH INSANITY OCCURS. Arch NeurPsych. 1924;11(3):282–291. doi:10.1001/archneurpsyc.1924.02190330032003