Something has been written of the connection of neurofibromatosis with endocrine disturbance. Most writers have called attention to the very frequent and, at times, marked pigmentation occurring in connection with the disease. Goodhart1 implicates the suprarenal glands but does not report results obtained in administering the gland extract. Involvement of the pituitary gland is suggested by Roubinovitch and de la Sourdière (quoted by Goodhart) who found acromegaloid changes in a mother and son with neurofibromatosis; Barber and Shaw2 reported a case with bilateral optic atrophy, sexual precocity and a shadow in the sella turcica thought to be that of a tumor, though not confirmed by operation or necropsy. Leir (quoted by Goodhart) found dystrophia adiposogenitalis, with roentgen-ray and ophthalmoscopic changes suggesting tumor of the pituitary in a boy; likewise unconfirmed by operation or necropsy.
Mallan3 reported the case of a boy, aged 8 years, who had pubic
TUCKER BR. VON RECKLINGHAUSEN'S DISEASE: WITH ESPECIAL CONSIDERATION OF THE ENDOCRINE CONNECTION. Arch NeurPsych. 1924;11(3):308–320. doi:10.1001/archneurpsyc.1924.02190330058005
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