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June 1924


Author Affiliations


From the Laboratory of Internal Medicine, Boston Psychopathic Hospital.

Arch NeurPsych. 1924;11(6):653-663. doi:10.1001/archneurpsyc.1924.02190360041002

In this paper are presented sugar estimations in 421 cases of mental and nervous disease, together with some observations on apparently normal persons.

Since 1852, when Deschamps and Bussy attempted to determine the nature of the reducing substance in the spinal fluid, medicine has been concerned with the significance and value of sugar estimations. Added impetus to the determination of the sugar in the spinal fluid as a clinical sign of importance was given by von Economo in 1917, when he published the first reliable statistics on the sugar content of the spinal fluid and on the chemistry of the blood in epidemic (lethargic) encephalitis. Since then, much work has been done on the nature, quantity, and significance of the reducing substance in the spinal fluid in various diseases, but little on the relation between the blood sugar and spinal fluid sugar. Mestrezat1 Hopkins,2 Fine and Myers,3

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