In the treatment of a group of neurosyphilitic patients with tryparsamide, an unusual opportunity was offered for the study of some problems of the arsenic permeability of the meninges. It is true that a considerable literature has been produced showing the arsenic content of the spinal fluid after intravenous injection of arsphenamin, neoarsphenamin, sulpharsphenamin, and other drugs; but the clinical success of tryparsamide in cases of neurosyphilis resistant to these drugs would lead one to believe that the arsenic content of the spinal fluid might differ appreciably under tryparsamide therapy. In addition, the size of the therapeutic dose of tryparsamide and its high arsenic content would make the technical estimation much simpler than in the case of the other drugs.
The material consists of spinal fluid from a total of 109 patients. Of these, ninety-two had received intravenous tryparsamide therapy; fifty-two of these followed meningeal irritation with autoserum. In addition
H. G. MEHRTENS, FRANK KOLOS, HELEN MARSHALL. TRYPARSAMIDE PENETRATION INTO THE CENTRAL NERVOUS TISSUE WITH AND WITHOUT SPINAL IRRITATIONCOMPARISON WITH ARSPHENAMIN. Arch NeurPsych. 1924;12(1):67–72. doi:10.1001/archneurpsyc.1924.02200010070002