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July 1924

TRYPARSAMIDE PENETRATION INTO THE CENTRAL NERVOUS TISSUE WITH AND WITHOUT SPINAL IRRITATIONCOMPARISON WITH ARSPHENAMIN

Author Affiliations

SAN FRANCISCO

From the laboratory of the Neuropsychiatric Clinic, Stanford University Medical School.

Arch NeurPsych. 1924;12(1):67-72. doi:10.1001/archneurpsyc.1924.02200010070002
Abstract

In the treatment of a group of neurosyphilitic patients with tryparsamide, an unusual opportunity was offered for the study of some problems of the arsenic permeability of the meninges. It is true that a considerable literature has been produced showing the arsenic content of the spinal fluid after intravenous injection of arsphenamin, neoarsphenamin, sulpharsphenamin, and other drugs; but the clinical success of tryparsamide in cases of neurosyphilis resistant to these drugs would lead one to believe that the arsenic content of the spinal fluid might differ appreciably under tryparsamide therapy. In addition, the size of the therapeutic dose of tryparsamide and its high arsenic content would make the technical estimation much simpler than in the case of the other drugs.

The material consists of spinal fluid from a total of 109 patients. Of these, ninety-two had received intravenous tryparsamide therapy; fifty-two of these followed meningeal irritation with autoserum. In addition

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