The treatment of tabes dorsalis and progressive paralysis through artificial malaria infection is based on the principle of a general nonspecific stimulation of the system to an increased defensive activity. While experiments along these lines have not been completed, it can already be said that a combination of specific and nonspecific measures will direct the future therapy in tabes dorsalis and progressive paralysis. It also seems proved that bismuth is the agent indicated for a combination in this sense. Combinations with arsphenamin have been endorsed by many authors. However, we do not advise these as a general measure for the following reasons: While it is certain that arsphenamin can also act as a nonspecific stimulant owing to its high content of arsenic, it cannot be denied that the toxic dose lies too near the therapeutic dose. In secondary stages in which conditions are entirely different a combination of nonspecific stimulation
AHLSWEDE EH. NONSPECIFIC STIMULATION THERAPY IN TABES DORSALIS. Arch NeurPsych. 1924;12(1):80–83. doi:10.1001/archneurpsyc.1924.02200010083004
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