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September 1924

THE SIGNIFICANCE OF CERTAIN FACTORS FOR THE DEVELOPMENT OF THE HEREDOFAMILIAL DISEASES OF THE NERVOUS SYSTEM: (CONSANGUINITY, RACE, ENDOCRINOPATHIES, TOXINS, INFECTIONS, ALCOHOLISM, ROENTGEN RAYS)

Arch NeurPsych. 1924;12(3):294-299. doi:10.1001/archneurpsyc.1924.02200030047004
Abstract

The newer studies of heredity have thrown some light on the relations of certain factors (such as those mentioned in the title) to the occurrence, or to the development, of the so-called heredofamilial diseases of the nervous system (limiting this term to diseases that occur in families because of their idiotypic or genotypic constitution). The patients who suffer from heredofamilial diseases of the nervous system become pathologic phenotypes, because of the idioplasm or germ plasm, that has resulted from the fusion of their parental gametes. By one parent, or by both, hereditary factors (ids or genes) responsible for the occurrence of the disease must have been transmitted. I shall discuss briefly the present state of knowledge concerning the significance of consanguinity, race and certain other influences for the development of the types of disease that are under consideration.

CONSANGUINITY  Biologists have long been interested in the origin of the taboo

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