[Skip to Content]
[Skip to Content Landing]
October 1924


Author Affiliations

Fellow of the National Research Council, Instructor in Surgery; Assistant Clinical Professor of Surgery SAN FRANCISCO

From the George William Hooper Research Foundation for Medical Research and the Division of Neurological Surgery, University of California Medical School.

Arch NeurPsych. 1924;12(4):411-418. doi:10.1001/archneurpsyc.1924.02200040054004

In the diagnosis and treatment of intracranial infections and neoplastic diseases, one desires more detailed anatomic knowledge of the cerebrospinal fluid system. Indeed, since the great contribution of Key and Retzius in 1875, little has been added to this knowledge, and the present work has been undertaken in a desire to correct this dearth of detailed information.

HISTORY  Galen,1 father of anatomy, and Vesalius,2 in the sixteenth century, described a thin membrane surrounding the brain underneath the dura, but neither of them recognized the arachnoid membrane or the subarachnoid space. In fact, the arachnoid was not established as a membrane separate from the pia mater until the middle of the seventeenth century. It was given its name by Blaes (Blasius),3 an anatomist of Amsterdam (1626-1682), arachnoid being derived from the Greek word ∥páϰm, meaning a spider's web. Soon afterward, Varioli, an Italian investigator, showed that this membrane