A marked increase in the total protein and in the number of cells in the cerebrospinal fluid was observed after the administration of Swift-Ellis serum by the intraspinal, intracistern or intraventricular route. Cerebrospinal fluids were studied with especial reference to these constituents in twenty-five cases in which treatment was administered by the intraspinal route, in twenty-one cases in which intracistern therapy had been given, and in five cases in which intraventricular treatment had been used. These patients had general paralysis, tabes dorsalis and cerebrospinal syphilis.
The method used in the protein determinations was that described by Denis and Ayer1 in 1920, and the normal standard was that of Ayer and Foster,2 who consider the limits of normal as being between 16 and 38 mg. per 100 c.c. and any total protein quantitation above 40 mg. as distinctly pathologic.
EFFECT ON LUMBAR SPINAL FLUID OF LUMBAR SUBARACHNOID INJECTION
YOUNG AW, ALPERS BJ. THE PROTEIN AND CELLULAR CONTENT OF THE CEREBROSPINAL FLUID: CHANGES IN THE FLUID FOLLOWING INTRASPINAL, INTRACISTERN AND INTRAVENTRICULAR THERAPY WITH SWIFT-ELLIS SERUM. Arch NeurPsych. 1924;12(5):537–546. doi:10.1001/archneurpsyc.1924.02200050052006
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