The association by clinicians of chorea with so-called acute rheumatic fever has had as a basis chiefly the necropsy findings in a few fatal cases. A review of the English literature has revealed that the necropsies were made by those primarily interested in the bacteriologic aspects of the situation or in pathologic investigations that were not thorough so far as the nervous system was concerned. Besides, these investigators did not have at their disposal the present day laboratory facilities and staining methods. In spite of this, Hughlings Jackson,1 sixty years ago, spoke of chorea associated with fatal cases of acute rheumatic fever as a meningo-encephalitis, and astonishingly enough localized the dominant nervous lesions in the "areas of the brain in and aroud the corpus striatum." H. C. Bastian2 said that he was convinced from a study of his necropsy material that fatal cases of chorea were types of
Osnato M, Casamajor L. MENINGO-ENCEPHALITIS ASSOCIATED WITH CARDITIS: Report of a Case with Necropsy Findings. Arch NeurPsych. 1924;12(5):553–558. doi:10.1001/archneurpsyc.1924.02200050068008
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