The term "amaurotic family idiocy" comprises a large group of disorders in which there are more or less definite pathologic changes. Here belong the infantile type of Tay1-Sachs,2 the late infantile variety described by Jansky,3 Schob,4 but especially well studied by Bielschowsky5 and the juvenile form of Vogt6 and Spielmeyer.7 Ichikawa8 accepts six varieties in which, he states, the changes, especially the retinal, as well as the clinical features are practically alike. Vogt, Spielmeyer and Bielschowsky also class with amaurotic family idiocy cases of exquisitely hereditary and familial cerebral disorders recorded by Pelizaeus,9 Higier,10 Merzbacher11 and one lately reported by Wolpert.12 However, like many other cases of blind idiocy, such as Winkler's,13 these have little in common, either clinically or anatomically, with the three well studied types mentioned above. Possessing common clinical features—blindness and progressive mental
HASSIN GB. A STUDY OF THE HISTOPATHOLOGY OF AMAUROTIC FAMILY IDIOCY (INFANTILE TYPE OF TAY-SACHS). Arch NeurPsych. 1924;12(6):640–662. doi:10.1001/archneurpsyc.1924.02200060041004
Customize your JAMA Network experience by selecting one or more topics from the list below.