Cases of hereditary and familial nervous diseases are comparatively rare, and complete necropsies of such cases are still more infrequent, although during past years a substantial amount of necropsy material has accumulated in several neurologic centers; the attention of investigators, with few exceptions, has been focused on the nervous system alone, or, as in cases of dystrophies, on the neuromuscular apparatus, and the extraneural systems have been more or less neglected. Of the numerous clinical and pathologic reports in the literature, few give the findings in detail.
Of the two great integrating mechanisms of the body, the nervous, and the circulatory system, the latter until recently has not received the attention its importance in this rôle should justify, since through its action, mechanical, metabolic and endocrine integrations are accomplished, and variations in structure and the alterations in function occurring therein may produce varying degrees of disorder in the organism as
LEWIS NDC. PATHOLOGIC PROCESSES IN EXTRANEURAL SYSTEMS OF BODY IN VARIOUS HEREDITARY AND FAMILIAL NERVOUS AND MENTAL DISEASES: IS THERE A FUNDAMENTAL SIMILARITY OF THESE? Arch NeurPsych. 1925;13(1):47–70. doi:10.1001/archneurpsyc.1925.02200070050004
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