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April 1925


Author Affiliations


From the Surgical Clinic of Dr. Harvey Cushing, Peter Bent Brigham Hospital, Boston.

Arch NeurPsych. 1925;13(4):423-470. doi:10.1001/archneurpsyc.1925.02200100002001

Tumors arising from the pineal body (the epiphysis cerebri) are among the rarer types of intracranial new growths. They are interesting from three points of view: first, from a purely neurologic standpoint, since they give rise to symptoms which have been of value in the localization of tumors in the pineal neighborhood; second, from the standpoint of the internal secretions, because of the much mooted question of a possible endocrine function of the organ; third, from a histopathologic standpoint, because of the peculiar and poorly understood structure of the epiphysis and consequently of the tumors which arise from it.

Numerous investigators have been inclined on an anatomic basis to believe in the glandular nature of the organ in question; and from their recent phylogenetic studies, Tilney and Warren1 have argued for such a belief. Physiologic experiments with pineal extract, however, have given negative results. Extirpation of the pineal body