The immunology of the cerebrospinal fluid in health and disease has long been a subject of considerable interest and importance, not only from the standpoint of theory and speculation regarding the source and mechanism of immunologic changes, but likewise in relation to natural and acquired resistance of the meninges, brain and cord to infection, and examinations of the fluid for diagnostic purposes.
IMMUNOLOGY OF NORMAL SPINAL FLUID
Before undertaking a discussion of the immunologic changes in the cerebrospinal fluid in disease and the mechanism of their production, it may be advisable first to make a brief survey of the immunology of the normal spinal fluid and the relation this subject bears to infection of the organs of the central nervous system. It has long been known that antibodies commonly found in the blood are not to be detected in the normal fluid. For example, that peculiar constituent of the plasma