This preliminary report on the cerebrospinal fluid sugar is based on the study of 425 spinal fluid and 150 whole blood or plasma sugar determinations made at the Massachusetts General Hospital during the past year. Folin and Wu's latest modification for blood sugar1 was the method used, the spinal fluid protein-free filtrate being prepared as recommended for blood plasma. The final dilutions were made in the modified sugar tubes recommended by Rothberg and Evans.2 Methods will be discussed in a later communication.
In 1852, Deschamp and Bussy3 found a reducing substance in the cerebrospinal fluid escaping from the ear of a patient with fractured skull. In 1897, Nawratski4 proved conclusively that this substance was glucose.
The relation of spinal fluid sugar to blood sugar has been a disputed subject. That the spinal fluid sugar is high and sometimes equals the blood sugar in diabetes mellitus is
FREMONT-SMITH F, DAILEY ME. CEREBROSPINAL FLUID SUGAR. Arch NeurPsych. 1925;14(3):390–395. doi:10.1001/archneurpsyc.1925.02200150103009
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