Although both the histopathologic and the clinical details of Tay-Sachs disease have been treated minutely, the general significance of this heredofamilial disease apparently is not properly recognized. I welcome the opportunity to publish a special paper on this in the United States, as America is the classical realm of investigations of this kind. It is sufficient to refer to the fundamental and excellent publications of Dr. B. Sachs, New York, and to the communications of Hirsch, Spiller, Strauss, Globus and other American authors.
I shall discuss: (1) the general points of view on the histopathology of Tay-Sachs disease; (2) the explanation of Tay-Sachs disease and of heredofamilial system disease by conclusions drawn from the histopathologic findings. I have dealt with both in my previous works, and I come back to these questions because the histopathology of Tay-Sachs disease has been enriched by interesting new contributions, and because the general conclusions