Lumbar puncture headache is one of the most difficult and trying complications with which the practitioner of medicine has to cope. There seems to be no way to predict whether headache will follow lumbar puncture, and no method of prevention when such a complication is suspected. Patients are often told that lumbar puncture is simple and harmless, only to find that it is followed by a severe and stubborn headache which incapacitates them for days and weeks, and which seems to resist all known forms of relief. Not only is this problem of great practical importance, but from a scientific point of view it is of great interest, for the cause of lumbar puncture headache is probably closely linked with the hydrodynamics of the cerebrospinal fluid.
I shall present studies in a series of cases of lumbar puncture headaches, and suggest a method of treatment which has proved to be
BERNARD J. ALPERS. LUMBAR PUNCTURE HEADACHE. Arch NeurPsych. 1925;14(6):806–812. doi:10.1001/archneurpsyc.1925.02200180077009