In 1901, Fröhlich1 published a comprehensive description of the syndrome that bears his name. The disease is characterized chiefly by fat dystrophy and genital hypoplasia or atrophy, and results, it is believed, from insufficiency of the hypophysis. Probably all lobes of the gland are involved.
The adiposity is a constant accompaniment in all cases of the disease and manifests itself usually in a more or less marked deposition of fat in the thighs, hips and lower part of the abdomen, giving rise to the so-called "girdle obesity." The genital changes, however, may vary, depending on the time of life during which the process develops. If it occurs at or before puberty, there results arrested development of the gonads, libido sexualis does not appear, the patient is sterile, and the organs of generation remain in the infantile state. If the syndrome appears after maturity, one of several changes may be
SHAPIRO S, KLIATSHCO MG. HYPOPHYSIAL FAT DYSTROPHY WITH HYPERGLYCEMIA AND GLYCOSURIA: REPORT OF A CASE. Arch NeurPsych. 1926;15(1):85–91. doi:https://doi.org/10.1001/archneurpsyc.1926.02200190088006
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