Epilepsy is one of those conveniently comprehensive terms, not infrequently found in medicine, that includes a number of different conditions. It is quite natural, therefore, that some difference of opinion should exist in regard to the spinal fluid findings. A large number of investigations have been made of the subject, none of which, however, reveal any specific, pathognomonic condition of the fluid. Boyd1 reports that, as a rule, there are no characteristic changes in the spinal fluid of epileptic patients. However, he finds a moderate lymphocytosis, with a corresponding increase in globulin, in a relatively high percentage of his patients. These findings and the paucity of recent examinations with newer technical methods seem to justify this study in which a comprehensive examination of the fluid has been attempted.
Fifty cases were selected from some 1,600 epileptic patients; they included a group of twenty-five men and one of twenty-five women