It has been the general experience in the clinical laboratory that the preparation of a proper colloidal gold solution, that is, a solution which will prove ideal for carrying out the colloidal gold test as applied to the differentiation of cerebrospinal syphilis, is often fraught with certain difficulties frequently not under the control of the worker. With due regard for the proper cleansing of glassware, the purity of the reagents entering into the preparation of such a solution and temperature precautions as laid down by those1 who have investigated the nature of colloid chemistry as highly necessary prerequisites for the achievement of a good product, it is not infrequently found that such solutions thus prepared are far from being suitable, if not altogether unsuitable, for the test proper.
Excluding those colloidal gold solutions that are grossly bad or self-condemnatory by their physical appearances, that is, either turbid or of
NOVICK N. THE CORRECTION OF COLLOIDAL GOLD SOLUTIONS AS APPLIED TO THE LANGE REACTION: A SIMPLE AND ACCURATE TITRATION METHOD. Arch NeurPsych. 1926;15(4):471–474. doi:10.1001/archneurpsyc.1926.02200220082004
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