The mere fact that the methods of treatment of general paralysis are so numerous and changeable denotes how unsatisfactory and unsettled they are. The great hopes aroused by arsphenamine and neo-arsphenamine preparations did not materialize, and new methods have been sought, of which two are at present commanding the attention of clinicians. These are tryparsamide and inoculations with malaria or relapsing fever. Enthusiastic as are the reports on the results with tryparsamide, they are much more so with malaria. The literature on both is already too extensive even for a brief review, and we shall therefore confine ourselves to the pathologic phase of this problem. Here we might point out that while a number of reports exist dealing with the pathologic changes obtaining in cases of general paralysis treated with malaria, none is available as to the conditions in cases treated with tryparsamide. As tryparsamide had been used rather intensively
HASSIN GB, BASSOE P. GENERAL PARALYSIS TREATED WITH TRYPARSAMIDE: A CLINICOPATHOLOGIC REPORT OF A CASE. Arch NeurPsych. 1926;16(1):37–47. doi:10.1001/archneurpsyc.1926.02200250040003
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