De Jong and Schaltenbrand obtained striking results following the administration of bulbocapnine hydrochloride and phosphate in various types of tremor diseases. As a result of their experiments it seemed desirable to gather further data on the action of bulbocapnine and also to make a comparison of its action with that of other drugs employed in the past for their reputed sedative and hypokinetic action on the central nervous system. In their first paper1 on the action of bulbocapnine on various types of tremor, these authors give a full account of its experimental history. It has been shown2 in animals that bulbocapnine causes catalepsy or a cataleptoid state. As a result of these findings, De Jong conceived the idea that these cataleptoid or hypokinetic states might be induced in tremor diseases by the action of bulbocapnine, owing to which the tremor would be diminished or overcome. The formula worked
DE JONG H, HERMAN W. THE ACTION OF BULBOCAPNINE IN THREE CASES OF PARALYSIS AGITANS AND ONE CASE OF TREMOR OF PARALYSIS AGITANS TYPE: A FURTHER NOTE, WITH A COMPARISON OF THE ACTION OF SCOPOLAMINE, ATROPINE AND PHENOBARBITAL. Arch NeurPsych. 1926;16(1):55–62. doi:10.1001/archneurpsyc.1926.02200250058005
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