Interest has been displayed in the constitutional factors which might be involved in schizophrenia, and with this interest has come the publication of studies concerning gross atrophies1 and histologic studies by Southard and Canavan,2 Mott3 and others. Southard,4 in 1910, as the result of his investigations, stated that the "evidence for the organic nature of dementia praecox was not wholly convincing." He found, however, a greater number of anomalies, external, visceral and cerebral, in schizophrenia than in the senile psychoses, the epilepsies and general paralysis, schizophrenia being second only to feeblemindedness in this respect. Attention has been focussed on the gonads3 and other ductless glands in connection with the increased interest in endocrines. Cotton5 has reported a large percentage of recoveries of so-called "functional mental disorder" after the removal of foci of infection, and lays special stress on such infections in causing mental disease.