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December 1926

A CASE OF AMAUROTIC FAMILY IDIOCY: LATE INFANTILE TYPE (BIELSCHOWSKY) WITH CLINICAL PICTURE OF DECEREBRATE RIGIDITY

Author Affiliations

Professor of Neurology, University of Illinois College of Medicine CHICAGO

From the Division of Neurology of the University of Illinois College of Medicine, and the Pathologic Laboratories of the State Psychopathic Institute and the Research and Educational Hospitals of the University of Illinois.

Arch NeurPsych. 1926;16(6):708-727. doi:10.1001/archneurpsyc.1926.02200300028002
Abstract

In contrast to the great number of clinical and pathologic reports on the infantile (Tay-Sachs) type of amaurotic family idiocy, reports on the juvenile and especially the so-called late infantile (Bielschowsky) types are scarce. This is most likely due to the fact that the last two varieties are rare and do not present such a clear cut clinical picture as the classic form of Tay-Sachs disease. For this reason also they are usually not recognized by clinicians but are accidental observations postmortem.

Described first by Jansky,1 cases of the late infantile variety of amaurotic family idiocy have been recorded by Schob,2 Brodmann3 and Marinesco,4 and have been especially well studied by Bielschowsky.5 The case here recorded is remarkable not only for its pathologic but also for its clinical features, which were those of decerebrate rigidity, and for the fact that the disease occurred in one

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