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February 1927

GENERAL PARALYSIS: THE HISTOPATHOLOGY OF THE BASAL GANGLIA, CORPUS CALLOSUM AND DENTATE NUCLEUS IN FOUR CASES

Author Affiliations

OMAHA

From the Laboratories of Neuropathology and the wards of the Philadelphia General Hospital.

Arch NeurPsych. 1927;17(2):214-230. doi:10.1001/archneurpsyc.1927.02200320066005
Abstract

My object in this paper is to describe the pathologic changes found in the basal ganglia in ordinary cases of general paralysis; not only are the changes definite and characteristic but also some of the signs typical of the disease may be explained on the basis of this pathologic condition. Such symptoms are the masklike or slightly expressionless facies, the speech defect and the involuntary tremors or twitchings of the small muscles of the face, especially about the eyes and the mouth.

In reviewing the literature of general paralysis, I have been able to find no detailed pathologic examination of the basal ganglia. Mella and Katz,1 in reporting a case of neurosyphilis with a parkinsonian syndrome, make this statement: "Inquiry at various pathologic laboratories has shown that the neuropathologic investigation of syphilis has usually been limited to a study of the cortex, medulla and spinal cord, neglecting the basal

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