The results of simultaneous investigation of analogous biologic processes may have significance reaching beyond an understanding of individual organs, for such study touches directly on the unity of the organism. The many analogies between the eyeball and the cranium have been emphasized by Thomson Henderson1 in 1910 and by Wegefarth and Weed2 in 1914, but Mestrezat,3 in 1912, established the fundamental identity of aqueous humor and cerebrospinal fluid.
These relationships have been discussed recently by one of us (F. F.-S.4) in a critical review on the nature of the cerebrospinal fluid. The evidence indicates that this fluid, and also the aqueous humor, both of which are nearly protein-free, are dialysates in equilibrium with the blood plasma. This concept, first formulated by Mestrezat,3 follows in the main the ideas on fluid exchange between capillaries and tissue spaces set forth by Starling5 in 1909; it assumes
FREMONT-SMITH F, FORBES HS. INTRA-OCULAR AND INTRACRANIAL PRESSURE: AN EXPERIMENTAL STUDY. Arch NeurPsych. 1927;18(4):550–564. doi:10.1001/archneurpsyc.1927.02210040057002
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