HistoricalSymptomatologyNeurologic signsLaboratory and Diagnostic MeasuresMental SymptomsCommentConclusionsThe difficulty of localization presented by several cases of tumors of the frontal1 lobe led to a critical review of the cases personally observed and of those from the records of the Neurological Clinic of the Hospital of the University of Pennsylvania, in an attempt: (1) to determine the features characteristic or suggestive of the development of tumors in this region; (2) to evaluate the importance of the various symptoms previously reported as of localizing value; (3) to consider the value of laboratory studies and other diagnostic procedures; (4) to estimate the diagnostic value of the mental state in the patients. The material of this series includes three cases personally studied and nineteen cases selected from the records of the Neurosurgical Clinic. Only those cases were selected which seemed predominantly to involve the frontal lobe and
KUBITSCHEK PE. THE SYMPTOMATOLOGY OF TUMORS OF THE FRONTAL LOBE: BASED ON A SERIES OF TWENTY-TWO CASES. Arch NeurPsych. 1928;20(3):559–579. doi:10.1001/archneurpsyc.1928.02210150119007
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