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January 1929


Author Affiliations


From the Pennsylvania Hospital, Department for Nervous and Mental Diseases, Philadelphia.

Arch NeurPsych. 1929;21(1):149-164. doi:10.1001/archneurpsyc.1929.02210190152010

There is a considerable literature, mostly foreign, on the use of insulin in states of undernutrition. The problem of critical undernutrition is a frequent one in the treatment of psychotic patients and moderate but apparently intractable undernutrition is not unusual in psychoneurotic patients. This article is a report on thirty-three patients treated with insulin in the Pennsylvania Hospital, with a brief review of the more important work that has been done on the use of insulin in nondiabetic conditions.

The alteration in sugar metabolism that may exist in thyroid disease1 led to the use of insulin in cases of hyperthyroidism. Goffin2 reported three cases of exophthalmic goiter in which the patients were treated with insulin and showed considerable improvement. A fourth patient with syphilis and exophthalmic goiter did not show any improvement on antisyphilitic treatment, but did improve when insulin was used. Lepine and Parturier3 reported the

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