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March 1929


Author Affiliations


From the Pathological Laboratory, St. Luke's Hospital.

Arch NeurPsych. 1929;21(3):607-612. doi:10.1001/archneurpsyc.1929.02210210133008

Recently, I reported a case in which four macroscopic aneurysms of the intracranial arteries were an incidental postmortem observation in a woman dying from uremia. While the aneurysms were large and were situated at the base of the brain, cerebral symptoms which could be related to them were not demonstrated. Because of a four plus Wassermann reaction of the spinal fluid, and because of the type of the cellular reaction seen microscopically in the wall of the aneurysms, they were interpreted in this case as being the result of syphilitic arterial disease. In a rather extensive review of the literature, multiple intracranial aneurysms of syphilitic origin appear to be extremely rare.

Since the report of this first case, two other patients with macroscopic intracranial aneurysms have come to autopsy at St. Luke's Hospital. Each patient died as the result of rupture of the aneurysm, and each case represents a different

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