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April 1929

THE CEREBRAL CIRCULATION: VI. THE EFFECT OF NORMAL AND OF INCREASED INTRACRANIAL CEREBROSPINAL FLUID PRESSURE ON THE VELOCITY OF INTRACRANIAL BLOOD FLOW

Author Affiliations

BOSTON

From the Thorndike Memorial Laboratory, Boston City Hospital, and the Departments of Neuropathology and Medicine of the Medical School of Harvard University.

Arch NeurPsych. 1929;21(4):795-804. doi:10.1001/archneurpsyc.1929.02210220066002
Abstract

Our purpose in this investigation was to study the effect of alterations in cerebrospinal fluid pressure on the intracranial velocity of blood flow. In previous communications1 were reported the results of direct observations through a tightly sealed glass window on the velocity of blood flow in cerebral vessels. By the method used, it was impossible to detect any but gross variations in the speed of blood flow. The following investigation was undertaken to study these changes more accurately.

METHOD 

Preparation of the Animal.  —Cats of approximately uniform size were used. The weights of the animals averaged 2.9 Kg., the largest differing from the smallest by 1.31 Kg. The heavier animals were pregnant, and so some of the weight may be discounted. Anesthesia was produced by intraperitoneal injection of from 8 to 9 cc. per kilogram of 1 per cent amytal (iso-amyl-ethyl barbituric acid). The animals were studied in the

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