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May 1929


Arch NeurPsych. 1929;21(5):1020-1043. doi:10.1001/archneurpsyc.1929.02210230034003

The coincidence of epilepsy and cerebral calcification is not a new observation. However, in this communication we are dealing with epilepsy of a peculiar type that appeared in one family, including the father and all four children. This, together with the fact that there was in each case also a peculiar type of cerebral calcification, justifies the assumption that we are dealing with a hitherto undescribed disease entity. There is strong evidence that the pathologic process in each case is primarily in the arterioles and capillaries of the cerebrum and presumptive evidence that the epileptic attacks have as their cause a vasomotor mechanism.

REPORT OF CASES  It seems best to present each member of the family in turn, although it has not been possible to study them all as completely as the patient in case 3.Case 1.—History.—Ev., a girl, aged 15, had been delivered at term with