The spontaneous discharge of spinal fluid from the nose is most often associated with tumor of the brain, and specifically with lesions that interfere with the normal circulation of the spinal fluid. In 1926, Locke1 reviewed the literature on this subject and found twelve fatal cases in which autopsy reports were sufficiently complete to permit definite conclusions concerning the cerebral and cranial changes associated with this condition. Internal hydrocephalus was present in all the cases, and in eight of them it had resulted from obstruction of the ventricular system caused by a tumor; in two cases, the hydrocephalus was of the congenital type with rhinorrhea developing in early adult life after the closure of the fontanels and sutures, and in two cases the hydrocephalus was classed as of the adult type. In these cases, in addition to the internal hydrocephalus and the increased intracranial pressure, an opening must exist
Gibbes JH. SPONTANEOUS CEREBROSPINAL RHINORRHEA: Report of a Case. Arch NeurPsych. 1929;21(5):1151–1153. doi:10.1001/archneurpsyc.1929.02210230165011
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