Cases of mesencephalic tumor associated with Argyll Robertson pupils in nonsyphilitic patients have been reported several times, but it does not appear to be generally recognized that this combination is of definite clinical and localizing significance.
In a recent book entitled "Modern Problems in Neurology" one of us (S. A. K. W.)1 devoted a chapter to the Argyll Robertson sign, and there recorded three personally observed instances of the combination, in only one of which, however, was the diagnosis confirmed by pathologic examination. With Rudolf, the same writer reported a characteristic example,2 in which the tumor had destroyed precisely the anterior corpora quadrigemina. At the International Neurological Conference held in Paris, in July, 1928, a similar case, with postmortem confirmation, was described by Professor Guillain.
Other instances from the sparse literature on the subject are that of Moeli3 (1887), in which a typical bilateral Argyll Robertson sign
WILSON SAK, GERSTLE M. THE ARGYLL ROBERTSON SIGN IN MESENCEPHALIC TUMORS. Arch NeurPsych. 1929;22(1):9–18. doi:10.1001/archneurpsyc.1929.02220010012003
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