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September 1929

LILLIPUTIAN HALLUCINATIONSReport of a Case of Hyoscine Poisoning.

Arch NeurPsych. 1929;22(3):585-588. doi:10.1001/archneurpsyc.1929.02220030162017

The atropine series contains a number of closely allied alkaloids, of which the chief are atropine, hyoscyamine and hyoscine or scopolamine. They are found in several plants of the order of Solanaceae, and in most cases several of them occur together. The chief plants containing these alkaloids are Atropa belladonna (deadly night shade), Hyoscyamus niger (henbane) and Datura stramonium (thornapple). The leaves of tobacco and potato, also of the order Solanaceae, contain minute quantities of these alkaloids. Hyoscine is apparently the least dangerous of the series, for while 0.5 mg. (1/120 grain) is sufficient to cause sleep, over 0.5 Gm. (7I/2 grains) has been administered to a small cat without causing death.1

Few cases of hyoscine poisoning are reported. In the famous Crippen case, in which Dr. Crippen was tried and convicted of poisoning his wife with hyoscine hydrobromide, Wilcox, by chemical and pharmacologic tests, demonstrated the presence of