The physiologic emphasis placed on the function of the arachnoid villi and the pacchionian granulations by Weed and his co-workers (1914-1923) has led us to a careful histologic and pathologic study. As the probable point of most active elimination of cerebrospinal fluid, their structure, development and reactions to disease should be of importance in many cases in which gross evidence of increased accumulation of cerebrospinal fluid over the cortex has been observed. These collections of cerebrospinal fluid demonstrated by encephalography, operation and necropsy suggested that the function of the structure concerned in elimination of the cerebrospinal fluid might be deficient.
Weed (1914-1923) demonstrated that the arachnoid villi, present at birth, develop in adult life into the well known pacchionian granules, and by the use of true colloidal solutions demonstrated that the major portion of cerebrospinal fluid finds its outlet through these structures. Weed's conclusions in his paper on "The Absorption
WINKELMAN NW, FAY T. THE PACCHIONIAN SYSTEM: HISTOLOGIC AND PATHOLOGIC CHANGES WITH PARTICULAR REFERENCE TO THE IDIOPATHIC AND SYMPTOMATIC CONVULSIVE STATES. Arch NeurPsych. 1930;23(1):44–64. doi:10.1001/archneurpsyc.1930.02220070047002
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