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April 1930

ACUTE, TOXIC (NONSUPPURATIVE) ENCEPHALITIS IN CHILDREN: A CLINICOPATHOLOGIC STUDY OF FIVE CASES

Arch NeurPsych. 1930;23(4):696-714. doi:10.1001/archneurpsyc.1930.02220100080004
Abstract

In the present study are recorded the clinicopathologic observations in five cases which may generally be classified as acute, toxic, non-suppurative encephalitis. The first three cases presented a rather unusual, though characteristic pathologic picture in the form of acute and peracute processes of liquefaction. In the last two cases, the pathologic changes were less characteristic and corresponded largely with the condition ordinarily described in toxic, noninflammatory lesions of the brain. The clinical features in cases 1 and 4 were discussed by Beverly,1 who, however, did not give a detailed pathologic description.

Nonsuppurative encephalitis has been known to occur: (1) as hemorrhagic encephalitis of the Struempell and Leichtenstern2 type; (2) as postinfectious encephalitis, a sequel both to the exanthematous diseases and to influenza, as described by Oppenheim,3 Abt4 and others; (3) as epidemic encephalitis. But in recent years, a series of cases has been reported by various

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