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June 1930

THE HISTOLOGY OF THE NERVOUS SYSTEMSOME OBSERVATIONS WITH THE ULTRAMICROSCOPE

Arch NeurPsych. 1930;23(6):1121-1137. doi:10.1001/archneurpsyc.1930.02220120026002
Abstract

This preliminary report is made on three of the simpler phases of a work which is designed to determine in what manner the methods of biology and physical chemistry can be made applicable to a study of the nervous system:

1. The ultramicroscopic observation of fresh nerve tissue reveals the colloidal nature of the tissue elements. This cannot be observed in fixed tissue with direct illumination.

2. In "swelling" experiments with fresh brain tissue, water is taken up in the proportions that are applicable to colloidal masses in general. The swelling of brain tissue thus follows the same laws as does that of gelatin, for instance. It is important to note that the swelling effects discussed are different from osmotic effects.

3. The effects of the colloidal swelling of the cells and intercellular substance of nerve tissue can be seen with the ultramicroscope. These appearances correlate with the results of

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