Some clinical manifestations of Niemann-Pick's disease, particularly those pertaining to the central nervous system, so much resemble the infantile form (type Tay-Sachs) of amaurotic family idiocy that the question naturally arises whether these two morbid conditions are not one disease. In a very few instances1 it was possible to show their identity by pathologic studies, while in rare instances it was possible to prove the presence in Niemann-Pick's disease of a cherry-red spot which is pathognomonic of the infantile form of amaurotic family idiocy. Though in the case recorded here such a spot was absent, the histologic as well as the gross changes were decidedly those of amaurotic family idiocy. There were some differences, which will be pointed out.
The clinical and general pathologic features of this case were typical of Niemann-Pick's disease. They will be recorded by Dr. Poncher and Dr. Boikan, while Mr. MacFate will report his
HASSIN GB. NIEMANN-PICK'S DISEASE: PATHOLOGIC STUDIES OF A CASE. Arch NeurPsych. 1930;24(1):61–70. doi:10.1001/archneurpsyc.1930.02220130064006
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