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The author is concerned mostly with "essential" or cryptogenic epilepsy. There are two factors to be considered: one the nervous, and the other the humoral. The present-day tendency centers the problem of the pathogenesis of epilepsy on the humoral factor. It is with this last factor that the author is principally concerned in this book.
Chapter I is a historical review of the experimental production of convulsions in animals with particular stress laid on the work of French and American authors, pointing out the combined effect of cerebral lesions and of toxic agents as the optimum condition to obtain experimental epilepsy. In chapter II the author points out the nonspecific character of lesions found post mortem from the standpoint of both their nature and their localization. The cerebral lesion is, however, an important though not absolute factor in the pathogenesis of epilepsy. The infections of the central nervous system are