The study of gliomatous tumors has been considerably advanced in recent years by the development and perfection of neuroglial staining methods. The credit for this should be given to the Spanish school of neurohistologists, notably Cajal and del Rio-Hortega. The methods of using gold and silver solutions of the former and the technic of silver carbonate staining with all its variations of the latter have brought to light many details of importance in the furtherance of knowledge of the structure of the neuroglia. To Cajal and his school is due much of the present knowledge of the histogenesis and structure of the astrocytic neuroglia, while del Rio-Hortega has demonstrated clearly the histogenesis, morphology and pathologic variations not only of the oligodendroglia, but also of the other constituent of the third element, the microglia or mesoglia. These studies have clarified remarkably the knowledge of the normal structure of the neuroglia and
ALPERS BJ. ORIGIN AND DEVELOPMENT OF GIANT CELLS IN GLIOMAS. Arch NeurPsych. 1931;25(2):281–298. doi:10.1001/archneurpsyc.1931.02230020067004
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