The regulation of body temperature in the warm-blooded animal is an old biologic problem. The physiologist has come to recognize in this mechanism a coordinated reflex act, which maintains a level body temperature in the normal animal by balancing the production with the elimination of heat. Such a delicately adjusted reflex mechanism is thought to be governed by a centralized nervous structure, and evidence is accumulating in favor of the existence of a subdivision in the brain that serves as a heat-regulating center. However, the exact site of this center is still in doubt. Many efforts have been made to localize it; many experiments have been performed, but as yet no conclusive results have been obtained establishing the exact location of such a center.
Among the several cerebral areas that are thought to contain a heat-regulating center is the corpus striatum. Aronson and Sachs1 produced experimentally a rise in
STRAUSS I, GLOBUS JH. TUMOR OF THE BRAIN WITH DISTURBANCE IN TEMPERATURE REGULATIONTHE HYPOTHALAMUS AND THE AREA ABOUT THE THIRD VENTRICLE AS A POSSIBLE SITE FOR A HEAT-REGULATING CENTER REPORT OF THREE CASES. Arch NeurPsych. 1931;25(3):506–522. doi:10.1001/archneurpsyc.1931.02230030064003
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