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June 1931

THE EQUILIBRIUM BETWEEN CEREBROSPINAL FLUID AND BLOOD PLASMA: II. THE COMPOSITION OF THE HUMAN CEREBROSPINAL FLUID AND BLOOD PLASMA IN MENINGITIS

Author Affiliations

BOSTON

From the Department of Neuropathology, Harvard Medical School; the Cerebrospinal Fluid Laboratory, Massachusetts General Hospital; the Neurological Laboratory and the Thorndike Memorial Laboratory, Boston City Hospital.

Arch NeurPsych. 1931;25(6):1290-1296. doi:10.1001/archneurpsyc.1931.02230060134006
Abstract

In this paper we present a comparative study of the sugar, nonprotein nitrogen, chloride1 and protein in parallel samples of blood plasma or serum and cerebrospinal fluid, in eighty-nine instances, on fifty patients, ranging in age from 2½ to 65 years. In addition, the freezing point depression, sodium, calcium, phosphorus and total solids have been determined in some of the cases. The methods used were described in the first paper of this series.1a

In table 1 are thirty instances of such parallel examinations in cases of tuberculous meningitis, in all of which the diagnosis was proved by autopsy, by guinea-pig inoculation of the cerebrospinal fluid or by finding tubercle bacilli in the cerebrospinal fluid by smear.

Table 2 is made up of eight instances of meningococcus meningitis, table 3 of eight instances of pneumococcus meningitis, table 4 of seven instances of streptococcus meningitis, table 5 of ten instances

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