The announcement, early in 1926, of the beneficial action of liver on the blood picture in pernicious anemia led neurologists to hope for similar success in combating the neurologic complications of the disease. Minot and Murphy1 lent some impetus to this hope when they stated: "Improvement of the neural symptoms has often been gratifying to the patient.... Recently developed symptoms have usually yielded more rapidly and satisfactorily than those due to long-standing lesions." Their experience showed that, with few exceptions, symptoms of the central nervous system did not develop or grow worse after the patient had been treated for one month. More extensive experience with liver, however, in cases of subacute combined degeneration has caused profound skepticism in certain quarters as regards both its prophylactic and its remedial properties.
It was with the idea of obtaining more exact information as to the effects of the use of liver in
NEEDLES W. NEUROLOGIC COMPLICATIONS OF PERNICIOUS ANEMIA: EFFECTS OF TREATMENT WITH LIVER; A PRELIMINARY REPORT. Arch NeurPsych. 1931;26(2):346–358. doi:10.1001/archneurpsyc.1931.02230080102006
Customize your JAMA Network experience by selecting one or more topics from the list below.